SKIN SCIENCE

Polynucleotides (PDRN) vs Hyaluronic Acid: Which Skin Booster Suits You?

Published August 18, 2026 • 6 min read • By Dr. Ramesh Bhanushali

Understanding Next-Generation Bio-Revitalization

While traditional dermal fillers and hyaluronic acid boosters excel at binding moisture in the extracellular matrix, Polynucleotides (PDRN) work upstream at the cellular level to stimulate fibroblast proliferation and repair damaged collagen fibers.

1. Mechanism of Action

PDRN chains derived from purified salmon DNA facilitate DNA nucleotide salvage pathways, effectively downregulating pro-inflammatory cytokines and accelerating angiogenesis in sun-damaged skin.

2. Who Benefits Most?

Patients with thin, crepey under-eye skin (tear troughs).
Individuals experiencing photo-aging and loss of dermal elasticity.
Those seeking progressive tissue regeneration with zero artificial volume distortion.

For bespoke consultation and protocol guidance, visit our Bandra West sanctuary.

Clinically Reviewed by Dr. Ramesh Bhanushali, BHMS, MD (Homoe), Post Graduation Diploma in Clinical Cosmetology and Trichology

Dr. Ramesh Bhanushali brings over a decade of specialized experience in clinical dermatology, laser aesthetics, and non-surgical facial rejuvenation in Mumbai.

★ 5+ Years Clinical Experience